Elucidation of molecular mechanisms of angiogenesis mediated by angiopoietins and its application for asthma therapy

阐明血管生成素介导的血管生成的分子机制及其在哮喘治疗中的应用

• 批准号: 20590901
• 负责人: KANAZAWA Hiroshi
• 金额: $ 2.91万
• 依托单位: Osaka City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590901/
• 关键词: 閉塞性肺疾患; VEGF; angioPoietin-1; angiopoietin-2; 血管新生; 肺血管内皮細胞; 肺微小循環系

Angiopoietin-1 has been shown to protect the adult vasculature against plasma leakage. In contrast, angiopoietin-2, an antagonist of angiopoietin-1, induces loosening of interactions between endothelial and perivascular support cells, and subsequently reduces vascular integrity. Thus, angiopoietin-1 and -2 may play complementary and coordinated roles in airway angiogenesis and microvascular remodeling.

血管生成素-1已被证明可以保护成人血管系统免受血浆渗漏。相反，血管生成素-1的拮抗剂血管生成素-2诱导内皮细胞和血管周围支持细胞之间相互作用的松动，随后降低血管完整性。因此，促血管生成素-1和-2可能在气道血管生成和微血管重塑中发挥互补和协调的作用。

项目成果

Increased levels of angiopoietin-2 in induced sputum from smoking asthmatic patients

• DOI: 10.1111/j.1365-2222.2009.03262.x
• 发表时间: 2009-09-01
• 期刊: CLINICAL AND EXPERIMENTAL ALLERGY
• 影响因子: 6.1
• 作者: Kanazawa, H.;Asai, K.;Hirata, K.
• 通讯作者: Hirata, K.

Angiopoietin-2 as a contributing factor in exercise-induced bronchoconstriction in asthmatic patients with inhaled corticosteroid therapy

血管生成素-2 作为吸入皮质类固醇治疗哮喘患者运动诱发支气管收缩的影响因素

• 发表时间: 2008
• 期刊: J Allergy Clin Immunol 121
• 作者: 友田恒一;他;Kanazawa H;Kanazawa H
• 通讯作者: Kanazawa H

Validity of measurement of two specific biomarkers for the assessment of small airways inflammation in asthma.

测量两种特定生物标志物用于评估哮喘小气道炎症的有效性。

• 发表时间: 2010
• 期刊: J Asthma. 47(4)
• 作者: Kanazawa H;Kyoh S;Asai K;Hirata K.
• 通讯作者: Hirata K.

誘発喀痰を用いた気道炎症の評価と治療モニタリング

使用诱导痰评估气道炎症和治疗监测

• 发表时间: 2008
• 作者: 友田恒一;大崎茂芳;吉川雅則;木村弘;金澤 博
• 通讯作者: 金澤 博

Increased levels of N^ε-(Carboxymethyl)Lysine in epithelial lining fluid from peripheral airways in patients with chronic obstructive pulmonary disease

慢性阻塞性肺疾病患者外周气道上皮衬液中 N^ε-（羧甲基）赖氨酸水平升高

• 发表时间: 2010
• 期刊: Clin Sci 119
• 作者: 友田恒一;他;Kanazawa H
• 通讯作者: Kanazawa H