Elucidation of molecular mechanisms of angiogenesis mediated by angiopoietins and its application for asthma therapy
Elucidation of molecular mechanisms of angiogenesis mediated by angiopoietins and its application for asthma therapy
批准号:
20590901
负责人:
KANAZAWA Hiroshi
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
Angiopoietin-1 has been shown to protect the adult vasculature against plasma leakage. In contrast, angiopoietin-2, an antagonist of angiopoietin-1, induces loosening of interactions between endothelial and perivascular support cells, and subsequently reduces vascular integrity. Thus, angiopoietin-1 and -2 may play complementary and coordinated roles in airway angiogenesis and microvascular remodeling.
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DOI:
10.1111/j.1365-2222.2009.03262.x
发表时间:
2009-09-01
期刊:
CLINICAL AND EXPERIMENTAL ALLERGY
影响因子:
6.1
作者:
[Kanazawa, H., Asai, K., Hirata, K.]
通讯作者:
Hirata, K.
Angiopoietin-2 as a contributing factor in exercise-induced bronchoconstriction in asthmatic patients with inhaled corticosteroid therapy
血管生成素-2 作为吸入皮质类固醇治疗哮喘患者运动诱发支气管收缩的影响因素
DOI:
--
发表时间:
2008
期刊:
J Allergy Clin Immunol 121
影响因子:
--
作者:
[友田恒一, 他, Kanazawa H, Kanazawa H]
通讯作者:
Kanazawa H
Validity of measurement of two specific biomarkers for the assessment of small airways inflammation in asthma.
测量两种特定生物标志物用于评估哮喘小气道炎症的有效性。
DOI:
--
发表时间:
2010
期刊:
J Asthma. 47(4)
影响因子:
--
作者:
[Kanazawa H, Kyoh S, Asai K, Hirata K.]
通讯作者:
Hirata K.
誘発喀痰を用いた気道炎症の評価と治療モニタリング
使用诱导痰评估气道炎症和治疗监测
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[友田恒一, 大崎茂芳, 吉川雅則, 木村弘, 金澤 博]
通讯作者:
金澤 博
Increased levels of N^ε-(Carboxymethyl)Lysine in epithelial lining fluid from peripheral airways in patients with chronic obstructive pulmonary disease
慢性阻塞性肺疾病患者外周气道上皮衬液中 N^ε-(羧甲基)赖氨酸水平升高
DOI:
--
发表时间:
2010
期刊:
Clin Sci 119
影响因子:
--
作者:
[友田恒一, 他, Kanazawa H]
通讯作者:
Kanazawa H
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NEW STRATEGY BASED ON REGULATION OF OXTPATIVE STRESS IN TREATMENT OF BRONCHIAL ASTHMA
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Art as Cultural Identity in Modern Nation-States
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国内基金
海外基金
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