pH regulation of organelles and its physiological role and molecular mechanism

Na+/H+交换剂。或Nha)存在于大多数生物体细胞的血浆或内体膜中。胞质pH维持在7，胞内内球pH维持在弱酸性。NHEs可调节胞质和内小体pH，但其生理功能尚不清楚。在本研究中，我们重点研究了定位于各种核内体的NHE的生理作用，并发现了细胞内蛋白质运输的新作用。

Na+/H+ exchangers (NHE. Or Nha) are found in the plasma or endosome membranes for the most cells of living organisms. Cytoplasmic pH is maintained at 7 while intracellular ensodome pH is set at weak acidic pH. NHEs are provided to regulate the cytoplasmic and endosome pH. However, their physiological function is still not clarified. In the present study, we focused on the physiological role of NHE localized at various endosomes and found a novel role in the intracellular protein trafficking.