A role of SHPS-1/CD47 signaling pathway in the glomerular barrier function

SHPS-1/CD47信号通路在肾小球屏障功能中的作用

• 批准号: 20590945
• 负责人: NOJIMA Yoshihisa
• 金额: $ 2.91万
• 依托单位: Gunma University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590945/
• 关键词: SHPS-1; SIRP-a; 糸球体バリアー機能; チロシン脱リン酸化; 情報伝達; CD47; SIRP-α

SHPS-1 (SIRP-α) is a transmembrane protein having ITIM motif in its cytoplasmic domain. When the ITIM motif in SHPS-1 is tyrosine-phospholylated by a variety of stimuli, SHPS-1 binds tyrosine phosphatases, SHP-1 or SHP-2, which dephospholylates neighboring proteins and transmits signals to downstream. In this study, we have shown that SHPS-1 is expressed on podocytes and plays a significant role in structure and function of podocytes by using mutant mice expressing SHPS-1 with a deleted cytoplasmic domain. The results strongly suggest that the tyrosine-dephosphorylation system is involved in maintaining the barrier function of glomerulus.

SHPS-1 （SIRP-α）是一种细胞质结构域具有ITIM基序的跨膜蛋白。当SHPS-1中的ITIM基序在各种刺激下被酪氨酸磷酸化时，SHPS-1结合酪氨酸磷酸酶SHP-1或SHP-2，使邻近蛋白去磷脂并向下游传递信号。在本研究中，我们利用缺失细胞质结构域表达SHPS-1的突变小鼠，证明了SHPS-1在足细胞上表达，并在足细胞的结构和功能中发挥重要作用。结果强烈提示酪氨酸-去磷酸化系统参与维持肾小球屏障功能。

项目成果

Proteomic analysis identifies insulin-like growth factor bindin protein-related protein 1 as a nodocvte product.

蛋白质组学分析将胰岛素样生长因子结合蛋白相关蛋白 1 鉴定为结节产物。

• 发表时间: 2010
• 期刊: Am J Physiol Renal Physiol.
• 作者: Matsumoto T;Nojima Y;et al
• 通讯作者: et al

SIRPα(SHPS-1)Signaling Pathway Is Involved in Podocyte Structure and Function

SIRPα(SHPS-1)信号通路参与足细胞结构和功能

• 发表时间: 2009
• 作者: Tomioka M;Hiromura K;Takahashi S;Takeuchi S;Maeshima A;Kuroiwa T;Kaneko Y;Saito Y;Ohnishi Y;Matozaki T;Aoki T;Takata T;Nojima Y
• 通讯作者: Nojima Y

Fluvastatin prevents podocyte injury in a murine model of HIV-associated nephropathy.

氟伐他汀可预防 HIV 相关肾病小鼠模型中的足细胞损伤。

• 发表时间: 2009
• 期刊: Nephrol Dial Transplant. 24(8)
• 作者: Sakurai N;Kuroiwa T;Ikeuchi H;Hiramatsu N;Takeuchi S;Tomioka M;Shigehara T;Maeshima A;Kaneko Y;Hiromura K;Kopp JB;Nojima Y.
• 通讯作者: Nojima Y.

The Role of SIRPα (SHPS-1) in Experimental Diabetic Nephr opathy.

SIRPα (SHPS-1) 在实验性糖尿病肾病中的作用。

• 发表时间: 2010
• 作者: Takahashi T;Hiromura K;Noiima Y;et al.
• 通讯作者: et al.

Nestin is a novel marker for renal tubulointerstitial injury in immunoelobulin A nenhronathv.

Nestin 是免疫球蛋白 A 肾小管间质损伤的新型标志物。

• 发表时间: 2010
• 期刊: Nephrology (Carlton).
• 作者: Tomioka M;Hiromura K;N oiima Y;et al
• 通讯作者: et al