A role of SHPS-1/CD47 signaling pathway in the glomerular barrier function

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SHPS-1 (SIRP-α) is a transmembrane protein having ITIM motif in its cytoplasmic domain. When the ITIM motif in SHPS-1 is tyrosine-phospholylated by a variety of stimuli, SHPS-1 binds tyrosine phosphatases, SHP-1 or SHP-2, which dephospholylates neighboring proteins and transmits signals to downstream. In this study, we have shown that SHPS-1 is expressed on podocytes and plays a significant role in structure and function of podocytes by using mutant mice expressing SHPS-1 with a deleted cytoplasmic domain. The results strongly suggest that the tyrosine-dephosphorylation system is involved in maintaining the barrier function of glomerulus.