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Study on the function of the transcriptional repressor Fbl10 in the regulation of c-Jun

Study on the function of the transcriptional repressor Fbl10 in the regulation of c-Jun
转录抑制因子Fbl10对c-Jun调控的功能研究
批准号：
20770154
负责人：
NASU Ryo
金额：
$2.83万
依托单位：
The University of Tokyo
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2008
资助国家：
日本
项目状态：
已结题
起止时间：
2008 至 2009
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20770154/
关键词：
クロマチン細胞周期c-JunJmjCHP1JmiCC-Jun

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中文摘要
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英文摘要
The transcriptional repressor Fbl10 is found to cooperate with Heterochromatin Protein 1 γ (HP1γ) to repress c-jun transcription. Moreover, HP1γ is dispensable for the tumorigenicity of colon cancer cells. Therefore, the increase of c-Jun by HP1γ repression may be involved in the induction of cell death, rather than the promotion of G1/S transition of cell cycle.
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The F-box protein Fbl10 is a novel transcriptional repressor of c-Jun
DOI： 10.1038/ncb1628
发表时间： 2007-09-01
期刊： NATURE CELL BIOLOGY
影响因子： 21.3
作者： [Koyama-Nasu, Ryo, David, Gregory, Tanese, Naoko]
通讯作者： Tanese, Naoko
Development of novel treatment strategies targeting the R-spondin-LGR-APC axis in glioblastoma stem cells
Development of therapy that targets ovarian clear cell carcinoma stem cells
Study of the function of the nuclear protein LDOC1 in the regulation of MDM2-mediated p53 ubiquitination
  • 批准号：
    22700871
  • 项目类别：
    Grant-in-Aid for Young Scientists (B)
  • 资助金额：
    $2.5万
  • 财政年份：
    2010
  • 负责人：
    NASU Ryo
  • 依托单位：
    The University of Tokyo
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