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Study of the function of the nuclear protein LDOC1 in the regulation of MDM2-mediated p53 ubiquitination

Study of the function of the nuclear protein LDOC1 in the regulation of MDM2-mediated p53 ubiquitination
核蛋白LDOC1调控MDM2介导的p53泛素化的功能研究
批准号:
22700871
负责人:
NASU Ryo
金额:
$2.5万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011

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中文摘要
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英文摘要
The nuclear protein LDOC1 is found to regulate the expressions of p53-target genes induced by DNA-damaging reagents. Moreover, p53-target genes are divided into the LDOC1-dependent and-independent groups. These data raise the possibility that LDOC1 is involved not only in the regulation of p53 stability but also in the control of the recruitment of p53.
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The critical role of cyclin D2 in glioblastoma stem cells
细胞周期蛋白 D2 在胶质母细胞瘤干细胞中的关键作用
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [那須亮, 西村教子, 藤堂具紀, 稲生靖, 齊藤延人, 油谷浩幸, 船戸洸佑, 越前佳奈恵, 春田諒, 松井真弓, 高橋理那, 小田健昭, 秋山徹]
通讯作者: 秋山徹
The molecular mechanisms of the regulation of Wnt signaling in glioblastoma stem cells
胶质母细胞瘤干细胞Wnt信号调控的分子机制
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [那須亮, 西村教子, 川崎善博, 藤堂具紀, 稲生靖, 武笠晃丈, 高柳俊作, 斉藤延人, 新井健明, 眞鍋瑛美, 秋山徹]
通讯作者: 秋山徹
Development of novel treatment strategies targeting the R-spondin-LGR-APC axis in glioblastoma stem cells
Development of therapy that targets ovarian clear cell carcinoma stem cells
Study on the function of the transcriptional repressor Fbl10 in the regulation of c-Jun
  • 批准号:
    20770154
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
  • 资助金额:
    $2.83万
  • 财政年份:
    2008
  • 负责人:
    NASU Ryo
  • 依托单位:
海外基金