Planar cell polarity of multi-ciliated ependymal cells

游动的纤毛在上皮组织上产生持续的液体流动，从而影响各种生理过程。纤毛细胞的这种功能取决于纤毛细胞的平面极性。在这里，我们报告了在分化过程中，基底小体在顶端细胞膜中移动，积聚在排列在脑室表面的室管膜细胞的前部。此外，我们还表明，非肌肉肌球蛋白II是这种基底体分布的关键调节因子。

Motile cilia generate constant fluid flow over epithelial tissue, and thereby influence diverse physiological processes. Such functions of ciliated cells depend on the planar polarity of the ciliated cells. Here we report that basal bodies move in the apical cell membrane during differentiation to accumulate in the anterior region of ependymal cells that line the surface of brain ventricles. Moreover, we show that non-muscle myosin II is a key regulator of this distribution of basal bodies.