Planar cell polarity of multi-ciliated ependymal cells

运动的纤毛在上皮组织上产生恒定的液体流动，从而影响不同的生理过程。纤毛细胞的这些功能依赖于纤毛细胞的平面极性。在这里，我们报告说，在分化过程中，基底体在顶细胞膜中移动，积聚在脑室表面的室管膜细胞的前部区域。此外，我们表明，非肌肉肌球蛋白II是一个关键的调节器，这种分布的基体。

Motile cilia generate constant fluid flow over epithelial tissue, and thereby influence diverse physiological processes. Such functions of ciliated cells depend on the planar polarity of the ciliated cells. Here we report that basal bodies move in the apical cell membrane during differentiation to accumulate in the anterior region of ependymal cells that line the surface of brain ventricles. Moreover, we show that non-muscle myosin II is a key regulator of this distribution of basal bodies.