Planar cell polarity of multi-ciliated ependymal cells

多纤毛室管膜细胞的平面细胞极性

• 批准号: 20770182
• 负责人: HIROTA Yuki
• 金额: $ 2.75万
• 依托单位: Nagoya City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20770182/
• 关键词: 細胞分化; 繊毛; 神経科学; 上衣細胞; 発生・分化; 再生医学

Motile cilia generate constant fluid flow over epithelial tissue, and thereby influence diverse physiological processes. Such functions of ciliated cells depend on the planar polarity of the ciliated cells. Here we report that basal bodies move in the apical cell membrane during differentiation to accumulate in the anterior region of ependymal cells that line the surface of brain ventricles. Moreover, we show that non-muscle myosin II is a key regulator of this distribution of basal bodies.

运动的纤毛在上皮组织上产生恒定的液体流动，从而影响不同的生理过程。纤毛细胞的这些功能依赖于纤毛细胞的平面极性。在这里，我们报告说，在分化过程中，基底体在顶细胞膜中移动，积聚在脑室表面的室管膜细胞的前部区域。此外，我们表明，非肌肉肌球蛋白II是一个关键的调节器，这种分布的基体。

项目成果

Polarization of ependymal cilia required for fluid flow in the adult mouse lateral ventricles

成年小鼠侧脑室液体流动所需的室管膜纤毛极化

• 发表时间: 2009
• 作者: Hirota Y;et al
• 通讯作者: et al

Various facets of vertebrate cilia : motility, signaling, and role in adult neurogenesis

脊椎动物纤毛的各个方面：运动、信号传导和在成体神经发生中的作用

• 发表时间: 2009
• 期刊: Proceedings of the Japan Academy (印刷中)
• 作者: 黄詩惠;et al
• 通讯作者: et al

Neurogenesis in the adult brain. (Neuronal Migration in The Adult Brain.) In press.

成人大脑中的神经发生。

• 作者: Sawada;M.;Huang;S.;Hirota;Y.;Kaneko;N.;Sawamoto;K.
• 通讯作者: K.

Cellular composition and organization of the subventricular zone and rostral migratory stream in the adult and neonatal common marmoset brain.

• DOI: 10.1002/cne.22543
• 发表时间: 2011-03-01
• 期刊: JOURNAL OF COMPARATIVE NEUROLOGY
• 影响因子: 2.5
• 作者: Sawamoto, Kazunobu;Hirota, Yuki;Alfaro-Cervello, Clara;Soriano-Navarro, Mario;He, Xiaoping;Hayakawa-Yano, Yoshika;Yamada, Masayuki;Hikishima, Keigo;Tabata, Hidenori;Iwanami, Akio;Nakajima, Kazunori;Toyama, Yoshiaki;Itoh, Toshio;Alvarez-Buylla, Arturo;Manuel Garcia-Verdugo, Jose;Okano, Hideyuki
• 通讯作者: Okano, Hideyuki

Ethel deficiency causes spontaneous myoclonus and increased seizure susceptibility

Ethel 缺乏会导致自发性肌阵挛和癫痫易感性增加

• 发表时间: 2009
• 期刊: Hum. Mol. Genet. 18
• 作者: Suzuki;T.;et.al.
• 通讯作者: et.al.