Identification of genes associated with differences in facial morphology among individuals and between populations

据推测，许多遗传多态与人类面部形态的变化有关。然而，他们的身份仍未确定。在本项目中，1)主要进行头面部形态的人体测量，2)在群体遗传学分析的基础上，从已知的与形态发生有关的基因中筛选候选基因，然后进行表型与基因的关联研究。在EDAR等几个基因中，发现了与包括牙齿形状在内的颅面形态有关的基因。

It is supposed that a number of genetic polymorphisms are associated with the variation in human facial morphology. However, they are still unidentified. In this project, to reveal such genes, 1) anthropometric measurements mainly in craniofacial morphology were performed, 2) based on population genetics analyses, candidate genes were selected from the genes known to be involved in morphogenesis, and then 3) association studies between phenotypes and genotypes were carried out. In several genes such as EDAR, associations with craniofacial morphology including tooth shape were identified.