Identification of genes associated with differences in facial morphology among individuals and between populations

鉴定与个体间和群体间面部形态差异相关的基因

• 批准号: 20770196
• 负责人: KIMURA Ryosuke
• 金额: $ 2.83万
• 依托单位: University of the Ryukyus
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20770196/
• 关键词: 分子; 遺伝; 人類学; ゲノム; 形態

It is supposed that a number of genetic polymorphisms are associated with the variation in human facial morphology. However, they are still unidentified. In this project, to reveal such genes, 1) anthropometric measurements mainly in craniofacial morphology were performed, 2) based on population genetics analyses, candidate genes were selected from the genes known to be involved in morphogenesis, and then 3) association studies between phenotypes and genotypes were carried out. In several genes such as EDAR, associations with craniofacial morphology including tooth shape were identified.

据推测，许多遗传多态性与人类面部形态的变化有关。然而，他们仍然身份不明。在本项目中，为了揭示这些基因，1)进行了以颅面形态学为主的人体测量，2)基于群体遗传学分析，从已知的参与形态发生的基因中选择候选基因，3)进行了表型与基因型之间的关联研究。在EDAR等几个基因中，发现了与颅面形态包括牙齿形状相关的基因。

项目成果

Handbook of Human Molecular Evolution

人类分子进化手册

• 发表时间: 2008
• 作者: Cooper DN;Kehrer-Sawatzki Heds
• 通讯作者: Kehrer-Sawatzki Heds

FGFR2 is associated with hair thickness in Asian populations

• DOI: 10.1038/jhg.2009.61
• 发表时间: 2009-08-01
• 期刊: JOURNAL OF HUMAN GENETICS
• 影响因子: 3.5
• 作者: Fujimoto, Akihiro;Nishida, Nao;Ohashi, Jun
• 通讯作者: Ohashi, Jun

Mapping Human Genetic Diversity in Asia

• DOI: 10.1126/science.1177074
• 发表时间: 2009-12-11
• 期刊: SCIENCE
• 影响因子: 56.9
• 作者: Abdulla, Mahmood Ameen;Ahmed, Ikhlak;Zilfalil, Bin Alwi
• 通讯作者: Zilfalil, Bin Alwi

ゲノムワイドSNPタイピングチップを用いたオセアニア人類集団における自然選択の探索

使用全基因组 SNP 分型芯片探索大洋洲人群的自然选择

• 发表时间: 2008
• 作者: Kimura R;Osawa M.;木村亮介
• 通讯作者: 木村亮介

A Common Variation in EDAR Is a Genetic Determinant of Shovel-Shaped Incisors

• DOI: 10.1016/j.ajhg.2009.09.006
• 发表时间: 2009-10-09
• 期刊: AMERICAN JOURNAL OF HUMAN GENETICS
• 影响因子: 9.8
• 作者: Kimura, Ryosuke;Yamaguchi, Tetsutaro;Oota, Hiroki
• 通讯作者: Oota, Hiroki