Analysis of lipid metabolites produced by gut flora and studies on the mechanism of anti-inflammatory activity exerted by the compounds
肠道菌群产生的脂质代谢物分析及其抗炎活性机制研究
基本信息
- 批准号:20780096
- 负责人:
- 金额:$ 2.75万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Young Scientists (B)
- 财政年份:2008
- 资助国家:日本
- 起止时间:2008 至 2009
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
It is known that various lipids are metabolized in vivo, and act as physiologically active substances. However, the participation of gut flora to lipid metabolism and the effect of lipid metabolites on gut immune system have yet to be fully elucidated. In this study, we tried to analyze lipid metabolites produced by intestinal microflora by using LC-MS/MS, though it had yet to be succeeded because of the effect of impurities. Meanwhile, we revealed that known lipid metabolites, including lipoxin A4 and resolvin E1, exert anti-inflammatory activity in intestinal tract.
众所周知,各种脂质在体内代谢,并作为生理活性物质。然而,肠道菌群对脂类代谢的参与以及脂类代谢物对肠道免疫系统的影响尚未完全阐明。在本研究中,我们尝试用LC-MS/MS分析肠道微生物产生的脂类代谢物,但由于杂质的影响,这一方法尚未成功。同时,我们发现已知的脂代谢产物,包括脂氧素A4和解决素E1,在肠道中具有抗炎活性。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Lipoxin A4 reduces lipopolysaccharide-induced inflammation in macrophages and intestial epithelial cells through inhibition of NF-κB activation.
Lipoxin A4 通过抑制 NF-κB 激活来减少巨噬细胞和肠上皮细胞中脂多糖诱导的炎症。
- DOI:
- 发表时间:2010
- 期刊:
- 影响因子:0
- 作者:Kure;I.;Nishiumi;S.;Nishitani;Y.;Tanoue;T.;Ishida;T.;Mizuno;M.;Fujita;T.;Kutsumi;H.;Arita;M.;Azuma;T.;Yoshida;M.
- 通讯作者:M.
Lipoxin A(4) reduces lipopolysaccharide-induced inflammation in macrophages and intestinal epithelial cells through inhibition of nuclear factor-kappaB activation.
Lipoxin A(4) 通过抑制核因子 kappaB 激活来减少巨噬细胞和肠上皮细胞中脂多糖诱导的炎症。
- DOI:
- 发表时间:2010
- 期刊:
- 影响因子:0
- 作者:Kure I、Nishiumi S、Nishitani Y;他8名
- 通讯作者:他8名
EPA由来生理活性物質の抗炎症作用
EPA 生理活性物质的抗炎作用
- DOI:
- 发表时间:2008
- 期刊:
- 影响因子:0
- 作者:Ishida;T.;Yoshida;M.;Arita;M.;Nishitani;Y.;Nishiumi;S.;Masuda;A.;Mizuno;S.;Takagawa;T.;Morita;Y.;Kutsumi;H.;Inokuchi;H.;Serhan;C.N.;Blumberg;R.S.;Azuma;T.;楠堂達也;西谷洋輔
- 通讯作者:西谷洋輔
Resolvin E1, an endogenous lipid mediator derived from eicosapentaenoic acid, prevents dextran sulfate sodium-induced colitis.
- DOI:10.1002/ibd.21029
- 发表时间:2010-01
- 期刊:
- 影响因子:4.9
- 作者:Ishida, Tsukasa;Yoshida, Masaru;Arita, Makoto;Nishitani, Yosuke;Nishiumi, Shin;Masuda, Atsuhiro;Mizuno, Shigeto;Takagawa, Tetsuya;Morita, Yoshinori;Kutsumi, Hiromu;Inokuchi, Hideto;Serhan, Charles N.;Blumberg, Richard S.;Azuma, Takeshi
- 通讯作者:Azuma, Takeshi
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NISHITANI Yosuke其他文献
NISHITANI Yosuke的其他文献
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{{ truncateString('NISHITANI Yosuke', 18)}}的其他基金
Search for food factors which regulate dendritic cells function via intestinal epithelial cells
寻找通过肠上皮细胞调节树突状细胞功能的食物因子
- 批准号:
23780134 - 财政年份:2011
- 资助金额:
$ 2.75万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
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