Analysis of lipid metabolites produced by gut flora and studies on the mechanism of anti-inflammatory activity exerted by the compounds
Analysis of lipid metabolites produced by gut flora and studies on the mechanism of anti-inflammatory activity exerted by the compounds
肠道菌群产生的脂质代谢物分析及其抗炎活性机制研究
批准号：
20780096
负责人：
NISHITANI Yosuke
金额：
$2.75万
依托单位：
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2008
资助国家：
日本
项目状态：
已结题
起止时间：
2008 至 2009
中文摘要
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英文摘要
It is known that various lipids are metabolized in vivo, and act as physiologically active substances. However, the participation of gut flora to lipid metabolism and the effect of lipid metabolites on gut immune system have yet to be fully elucidated. In this study, we tried to analyze lipid metabolites produced by intestinal microflora by using LC-MS/MS, though it had yet to be succeeded because of the effect of impurities. Meanwhile, we revealed that known lipid metabolites, including lipoxin A4 and resolvin E1, exert anti-inflammatory activity in intestinal tract.
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Lipoxin A4 reduces lipopolysaccharide-induced inflammation in macrophages and intestial epithelial cells through inhibition of NF-κB activation.
Lipoxin A4 通过抑制 NF-κB 激活来减少巨噬细胞和肠上皮细胞中脂多糖诱导的炎症。
Lipoxin A4 通过抑制 NF-κB 激活来减少巨噬细胞和肠上皮细胞中脂多糖诱导的炎症。
DOI：
--
发表时间：
2010
期刊：
J.Pharmacol. Exp.Ther. 332
影响因子：
--
作者：
[Kure, I., Nishiumi, S., Nishitani, Y., Tanoue, T., Ishida, T., Mizuno, M., Fujita, T., Kutsumi, H., Arita, M., Azuma, T., Yoshida, M.]
通讯作者：
M.
Lipoxin A(4) reduces lipopolysaccharide-induced inflammation in macrophages and intestinal epithelial cells through inhibition of nuclear factor-kappaB activation.
Lipoxin A(4) 通过抑制核因子 kappaB 激活来减少巨噬细胞和肠上皮细胞中脂多糖诱导的炎症。
Lipoxin A(4) 通过抑制核因子 kappaB 激活来减少巨噬细胞和肠上皮细胞中脂多糖诱导的炎症。
DOI：
--
发表时间：
2010
期刊：
J Pharmacol Exp Ther. 332
影响因子：
--
作者：
[Kure I、Nishiumi S、Nishitani Y, 他8名]
通讯作者：
他8名
DOI：
10.1002/ibd.21029
发表时间：
2010-01
期刊：
INFLAMMATORY BOWEL DISEASES
影响因子：
4.9
作者：
[Ishida, Tsukasa, Yoshida, Masaru, Arita, Makoto, Nishitani, Yosuke, Nishiumi, Shin, Masuda, Atsuhiro, Mizuno, Shigeto, Takagawa, Tetsuya, Morita, Yoshinori, Kutsumi, Hiromu, Inokuchi, Hideto, Serhan, Charles N., Blumberg, Richard S., Azuma, Takeshi]
通讯作者：
Azuma, Takeshi
EPA由来生理活性物質の抗炎症作用
EPA 生理活性物质的抗炎作用
EPA 生理活性物质的抗炎作用
DOI：
--
发表时间：
2008
期刊：
影响因子：
--
作者：
[Ishida, T., Yoshida, M., Arita, M., Nishitani, Y., Nishiumi, S., Masuda, A., Mizuno, S., Takagawa, T., Morita, Y., Kutsumi, H., Inokuchi, H., Serhan, C.N., Blumberg, R.S., Azuma, T., 楠堂達也, 西谷洋輔]
通讯作者：
西谷洋輔
Search for food factors which regulate dendritic cells function via intestinal epithelial cells
-
批准号：23780134
-
项目类别：Grant-in-Aid for Young Scientists (B)
-
资助金额：$2.91万
-
财政年份：2011
-
负责人：NISHITANI Yosuke
-
依托单位：
海外基金