Clarification of the Toll-like receptor 2-mediated anti-allergic function of fermented milk-derived microorganisms

发酵乳来源微生物的 Toll 样受体 2 介导的抗过敏功能的阐明

• 批准号: 20780191
• 负责人: KAWAHARA Takeshi
• 金额: $ 2.75万
• 依托单位: Shinshu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20780191/
• 关键词: マスト細胞; アレルギー; 乳酸菌; 脱顆粒反応; FcεRI; Tollと様受容体2; TLR2; I型アレルギー

This study investigated the suppressive function of fermented milk-derived microorganisms that work as the ligand of Toll-like receptor 2. The strong suppressive effect of lactic acid bacterial strain (Lactobacillus reuteri NBRC15892) on both degranulation and subsequent late-phase reactions (induction of proinflammatory cytokines and production of lipid mediators) of mast cells are elucidated by the screening and investigation using this strain.

本研究研究了发酵乳源微生物作为toll样受体2的配体的抑制功能。乳酸菌菌株（Lactobacillus reuteri NBRC15892）对肥大细胞的脱肉芽和随后的后期反应（诱导促炎细胞因子和脂质介质的产生）的强烈抑制作用通过对该菌株的筛选和研究得到阐明。

项目成果

Anti-Allergic Effect of a Hot-Water Extract of Quince (Cydonia oblonga)

• DOI: 10.1271/bbb.90130
• 发表时间: 2009-08-01
• 期刊: BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
• 影响因子: 1.6
• 作者: Shinomiya, Fumie;Hamauzu, Yasunori;Kawahara, Takeshi
• 通讯作者: Kawahara, Takeshi

脱顆粒反応抑制乳酸菌のマウス骨髄由来マスト細胞遅延相応答に対する抑制効

乳酸菌对小鼠骨髓源性肥大细胞延迟相反应的抑制作用

• 发表时间: 2009
• 作者: 河原岳志;大谷元
• 通讯作者: 大谷元

Inhibitory effect of heat-killed Lactobacillus strain on immunoglobulin E-mediated degranulation and late-phase immune reactions of mouse bone marrow-derived mast cells.

• DOI: 10.1111/j.1740-0929.2010.00788.x
• 发表时间: 2010-12
• 期刊: Animal science journal = Nihon chikusan Gakkaiho
• 作者: T. Kawahara

発酵乳由来微生物のマウスマスト細胞に及ぼす影響の評価

发酵乳源微生物对小鼠肥大细胞影响的评价

• 发表时间: 2009
• 作者: 河原岳志;大谷元
• 通讯作者: 大谷元

Bacteriocinogenic lactic acid bacteria Lactobacillus curvatus strain Y108 isolated from Nozawana-zuke pickles

从 Nozawana-zuke 泡菜中分离出的致细菌乳酸菌弯曲乳杆菌菌株 Y108

• 发表时间: 2010
• 期刊: Food Science and Technology Research 16
• 作者: Kawahara;T.;Iida;A.;Toyama;Y.;Fukuda;K.
• 通讯作者: K.