Molecular and cellular biological studies on diversity of inclusion bodies and pathogenesis of Chlamydophila psittaci.

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cell cytoplasm, called "inclusion body". In this study, aiming at understanding the relationship between biogenesis of inclusion bodies of Chlamydophila psittaci, a causative agent for a zoonotic psittacosis, and its pathogenesis. As a result of C. psittaci library screening by using C. psittaci-infection specific serum, the clone encoding one of the polymorphic membrane protein (pmp) genes was obtained (temporary named as PmpX), and functional analysis of PmpX was done. Currently, further investigation of the role of C. psittaci Pmp family proteins (especially PmpX) in biogenesis of chlamydial inclusion bodies and in pathogenesis are on going.