Study for accelerating effect of brain-derived neurotrophic factor on methylmercury-induced neuronal death

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Brain-derived neurotrophic factor (BDNF) is a maintenance protein for neuronal function and survive, but also stimulate methylmercury-induced neuronal cell death. In the present study, to expose mechanisms of the BDNF stimulation, we investigate using rat cerebellar granular cell culture system. Neurotrophin-4, another TrkB ligand, stimulated methylmercury-induced cell death. The stimulating effect of BDNF on the cell death was inhibited by treatment of anti-BDNF antibody that prevents BDNF from binding to TrkB. The results indicated that the stimulation by BDNF needs the BDNF binding to TrkB, which suggested BDNF/TrkB play as a sensitivity determiant factor.