Analysis for regulation of transcription factor FOXO1 by post-translational modification and mechanism of determination of lifspan

在氧化应激反应中，叉头转录因子FOXO1被激活，从而促进抗氧化基因的表达。此外，FOXO已被证明是模式生物的寿命调节剂。在这里，我们已经证明了翻译后修饰在fox01功能的调控中起着重要作用。此外，通过线虫的遗传实验，我们发现FOXO1的精氨酸甲基化参与了寿命的调节。

In response to oxidative stress, the Forkhead transcription factor FOXO1 is activated and thereby promotes the expression of anti-oxidant genes. Moreover, FOXO has been shown to act as lifespan modulator in model organisms. Here we have demonstrated that post-translational modification plays an important role in regulation of FOXO1 function. Furthermore, by using genetic experiments in C. elegans, we have revealed that arginine methylation of FOXO1 is involved in the regulation of lifespan.