Functional analysis of DNA damage response of transcription factor FOXO1 in lifespan regulation

转录因子FOXO 1被认为参与延长寿命和抗衰老;然而，其分子机制仍不清楚。在这项研究中，我们发现FOXO 1有助于跨导DNA合成，这是对紫外线（UV）照射的DNA损伤反应。此外，利用C. elegans的研究表明，FOXO 1/FOXO-16在幼虫发育过程中的UV抗性中起着至关重要的作用。这一发现将有助于阐明FOXO 1的抗衰老机制。

Transcription factor FOXO1 is known to be involved in lifespan extension and anti-aging; however, the molecular mechanism remains unclear. In this study, we found that FOXO1 contributes to tlanslesion DNA synthesis, which serves as the DNA damage response against ultra violet (UV) irradiation. Furthermore, genetic analysis using C. elegans showed that FOXO1/DAF-16 plays a crucial role in UV resistance during larval development. Our finding will help to elucidate the anti-aging mechanism of FOXO1.