The nuclear function of nonreceptor tyrosine kinases.

点击翻译按钮获取中文摘要

Nonreceptor tyrosine kinases (NRTKs) work under plasma membrane in combination with transmembrane receptors, but recent reports showed that these NRTKs can translocate to the nucleus. We found that NRTKs regulate DNA damage checkpoint, chromatin condensation associated by apoptosis and nuclear structure through nuclear protein tyrosine phosphorylation, and analyzed the molecular mechanisms. These results give novel insights into the use of molecular-targeting anti-cancer drugs and the improvement of chemotherapy and radiation therapy.