The regulation of G2 DNA damage checkpoint recovery by Src family kinases

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We showed that the regulation of DNA damage checkpoint recovery by Src family kinases involves the regulation of ATR-dependent Rad17 phosphorylation as a key event, and that the underlying molecular mechanism involves the inhibition of the interaction between Rad17 and Rad9. Src family kinases are also involved in ATM-Chk2 checkpoint pathway and replication checkpoint recovery. We also showed the regulation of Kap1 and Cdc5L by tyrosine phosphorylation and the regulation of checkpoint recovery by imatinib. These data shed light on the role of Src family kinases in the termination of DNA damage checkpoint signaling.