The analysis of cellular osmotic stress response focusing on a novel kinase ASK3
The analysis of cellular osmotic stress response focusing on a novel kinase ASK3
批准号:
20790058
负责人:
NAGURO Isao
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009
中文摘要
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英文摘要
We found that ASK3 responds to osmotic stress in the cell and alters its kinase activity by the osmotic change. We investigated the molecular mechanism how ASK3 alters the kinase activity and we suggested that ASK3 may play an important role in water and ion regulation, especially in blood pressure regulation of the body.
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The roles of ASK family proteins in stress responses and diseases.
问家族蛋白在压力反应和疾病中的作用。
DOI:
10.1186/1478-811x-7-9
发表时间:
2009-04-24
期刊:
Cell communication and signaling : CCS
影响因子:
--
作者:
[Hattori K, Naguro I, Runchel C, Ichijo H]
通讯作者:
Ichijo H
A novel MAP3K, ASK3 regulates WNK-SPAK/OSR1 signal transduction in osmotic stress response
一种新型 MAP3K,ASK3 调节渗透应激反应中的 WNK-SPAK/OSR1 信号转导
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Naguro, I., et.al.]
通讯作者:
et.al.
ASK3は浸透圧ストレスに両方向性に応答しWNK1-SPAK/OSR1経路の抑制因子として働く
ASK3 双向响应渗透压并充当 WNK1-SPAK/OSR1 通路的抑制剂
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[名黒功, 梅田剛, 丸山順一, 武田弘資, 一條秀憲]
通讯作者:
一條秀憲
Apoptosis Signal-regulating Kinase 1 (ASK1) in stress and immune response.
应激和免疫反应中的凋亡信号调节激酶 1 (ASK1)。
DOI:
--
发表时间:
2008
期刊:
Annu. Rev. Pharmacol. Toxicol. 48
影响因子:
--
作者:
[Takeda, K., et. al.]
通讯作者:
et. al.
DOI:
10.1038/emboj.2009.32
发表时间:
2009-04-08
期刊:
EMBO JOURNAL
影响因子:
11.4
作者:
[Iriyama, Takayuki, Takeda, Kohsuke, Ichijo, Hidenori]
通讯作者:
Ichijo, Hidenori
共 13 条
A genome-wide RNAi screening for clarifying the molecular mechanism of osmotic stress response in the mammalian cell
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批准号:25650004
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
-
财政年份:2013
-
负责人:NAGURO Isao
-
依托单位:
The analysis of cellular osmotic stress sensing and response by focusing onASK3
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批准号:23790078
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.83万
-
财政年份:2011
-
负责人:NAGURO Isao
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依托单位:
海外基金