Roles of hydrogen peroxide as intercellular signaling molecule after neural cell injury

在大鼠皮质纹状体脑片培养中，过氧化氢诱导胶质细胞中多种细胞因子/趋化因子如MCP-1和IL-6表达上调。观察两种自由基清除剂依达拉奉和二甲基硫脲对过氧化氢诱导的细胞损伤和细胞因子/趋化因子产生的影响。依达拉奉和二甲基硫脲均能抑制过氧化氢诱导的细胞损伤。二甲基硫脲抑制过氧化氢诱导的细胞因子/趋化因子表达增加，而依达拉奉不改变这些细胞因子/趋化因子的表达。

In rat corticostriatal slice cultures, hydrogen peroxide exposure induced upregulation of various cytokines/chemokines such as MCP-1 and IL-6 in glial cells. The effects of two free radical scavengers edaravone and dimethylthiourea on hydrogen peroxide-induced cell injury and the production of cytokines/chemokines were examined. Hydrogen peroxide-induced cell injury was inhibited by both edaravone and dimethylthiourea. On the other hand, dimethylthiourea inhibited the increased expression of cytokines/chemokines by hydrogen peroxide, whereas edaravone did not alter the expression of these cytokines/chemokines.