Molecular Basis of the regulation of ETS transcription factor MEF expression by tumor suppressor gene p53

抑癌基因p53调控ETS转录因子MEF表达的分子基础

• 批准号: 20790068
• 负责人: ANN SOTEN Suico mary
• 金额: $ 2.75万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790068/
• 关键词: 薬理学; MEF; ETS; p53; E2F; p21; Myeloid elf-1 like factor (MEF); Sp1; E2F1; プロモーター; 転写; Meloid elf-1 like factor(MEF)

MEF is one of the ETS transcription factors which regulates a diverse range of innate immune molecules including antibacterial peptides, cytokines and innate immune cell progression. In the present study, we investigated the role of tumor suppressor gene p53 in the regulation of MEF expression. We demonstrate that p53 directly binds to E2F1 and inhibits E2F1 binding to MEF promoter, thereby suppressing MEF transcription.

MEF是ETS转录因子之一，调节多种天然免疫分子，包括抗菌肽、细胞因子和天然免疫细胞进程。在本研究中，我们研究了抑癌基因P53在MEF表达调控中的作用。我们证明了P53直接与E2F1结合，并抑制E2F1与MEF启动子的结合，从而抑制MEF转录。

项目成果

Role of calnexin in the ER quality control and productive folding of CFTR; differential effect of calnexin knockout on wild-type and DF508 CFTR. Biochem

钙联蛋白在 ER 质量控制和 CFTR 有效折叠中的作用；

• 发表时间: 2008
• 期刊: Biochim. Acta (Mol. Cell Res. ) 1783
• 作者: Okiyoneda T.;Niibori A.;Harada K.;Kohno T.;Michalak M.;Duszyk M.;Wada I.;Ikawa M.;Shuto T.;Suico M. A;Kai H.
• 通讯作者: Kai H.

The Endoplasmic Reticulum-associated Degradation of Transthyretin Variants Is Negatively Regulated by BiP in Mammalian Cells*

• DOI: 10.1074/jbc.m809354200
• 发表时间: 2009-03
• 期刊: Journal of Biological Chemistry
• 影响因子: 4.8
• 作者: S. Susuki;Takashi Sato;M. Miyata;Mamiko Momohara;M. Suico;T. Shuto;Y. Ando;H. Kai

Interferon-gamma down-regulated Hsp27 and enhances hyperthermia-induced tumor cell death in vitro and tumor suppression in vivo

干扰素-γ 下调 Hsp27，增强体外热疗诱导的肿瘤细胞死亡和体内肿瘤抑制

• 发表时间: 2008
• 期刊: Int. J. Oncol 32
• 作者: Oba M;et.al.
• 通讯作者: et.al.

and Hirofumi Kai Phosphatidic acid metabolism regulate the intracellular trafficking and retrotranslocation of cystic fibrosis transmembrane conductance regulator

和 Hirofumi Kai 磷脂酸代谢调节囊性纤维化跨膜电导调节剂的细胞内运输和逆转位

• 发表时间: 2008
• 期刊: Biochem. Biochim. Acta (Mol. Cell Res. ) 1783
• 作者: Yasuaki Hashimoto;Tsukasa Okiyoneda;Kazutsune Harada;Keiko Ueno;Takuya Sugahara;Atsushi Yamashita;Tsuyoshi Shuto;Mary Ann Suico
• 通讯作者: Mary Ann Suico

p53 is a critical factor for TLR3 expression and TLR3-mediated cytokine induction in epithelial cells

p53 是上皮细胞中 TLR3 表达和 TLR3 介导的细胞因子诱导的关键因素

• 发表时间: 2008
• 作者: Morino S;et.al.;スイコメリーアン;A. Eguma;Manabu Taura
• 通讯作者: Manabu Taura