Development of bioactive peptide derivative and dry powder inhalation system for treatment of COPD

治疗慢性阻塞性肺病的生物活性肽衍生物及干粉吸入系统的开发

• 批准号: 20790103
• 负责人: ONOUE Satomi
• 金额: $ 2.75万
• 依托单位: University of Shizuoka
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790103/
• 关键词: 慢性閉塞性肺疾患; 血管作働性腸管ペプチド; 粉末吸入製剤

We developed some VIP derivative with improved stability, and dry powder inhaler system of VIP derivative was also designed for inhalation therapy. Intratracheal administration of VIP-based respirable powder led to significant attenuation of inflammatory events in COPD model rats.

我们研制了一些稳定性较好的VIP衍生物，并设计了VIP衍生物的干粉吸入系统。VIP可吸入粉末的肠内给药导致COPD模型大鼠的炎症事件显著减弱。

项目成果

新規VIP誘導体微細化粉末製剤の抗炎症作用

新型VIP衍生物微粉制剂的抗炎作用

• 发表时间: 2008
• 作者: 三坂眞元;尾上誠良;ほか
• 通讯作者: ほか

In vitro and in vivo characterization on amorphous solid dispersion of cyclosporine A for inhalation therapy.

• DOI: 10.1016/j.jconrel.2009.04.014
• 发表时间: 2009-08
• 期刊: Journal of controlled release : official journal of the Controlled Release Society
• 作者: S. Onoue;Hideyuki Sato;Yohei Kawabata;T. Mizumoto;N. Hashimoto;S. Yamada

Novel dry powder formulation of ovalbumin for development of COPD-like animal model: Physicochemical characterization and biomarker profiling in rats

• DOI: 10.1016/j.ejps.2009.04.002
• 发表时间: 2009-06-28
• 期刊: EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
• 影响因子: 4.6
• 作者: Misaka, Shingen;Sato, Hideyuki;Yamada, Shizuo
• 通讯作者: Yamada, Shizuo

Novel crystalline solid dispersion of tranilast with high photostability and improved oral bioavailability

• DOI: 10.1016/j.ejps.2009.12.009
• 发表时间: 2010-02-19
• 期刊: EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
• 影响因子: 4.6
• 作者: Kawabata, Yohei;Yamamoto, Kiyoshi;Yamada, Shizuo
• 通讯作者: Yamada, Shizuo

Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Attenuates Streptozotocin-Induced Apoptotic Death of RIN-m5F Cells Through Regulation of Bcl-2 Family Protein mRNA Expression

垂体腺苷酸环化酶激活多肽 (PACAP) 通过调节 Bcl-2 家族蛋白 mRNA 表达减轻链脲佐菌素诱导的 RIN-m5F 细胞凋亡

• 发表时间: 2009
• 期刊: FEBS Journal 275巻
• 作者: Satomi;Onoue;ほか
• 通讯作者: ほか