Formulation studies on neuropeptides for type-2 diabetes treatment

神经肽治疗2型糖尿病的制剂研究

• 批准号: 22790043
• 负责人: ONOUE Satomi
• 金额: $ 2.58万
• 依托单位: University of Shizuoka
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790043/
• 关键词: ドラッグデリバリー; ペプチド創薬; ペプチド創剤; 糖尿病; 2型糖尿病; 神経ペプチド; インスリン分泌促進; アポトーシス

The present study aimed to develop new therapeutic agent to treat type 2 diabetes with a focus on glucagon-secretin family neuropeptides. Biochemical studies and structure-activity relationship studies were undertaken to provide new promising derivatives of neuropeptides. To improve therapeutic compliance for neuropeptides, sustained-release dry powder formulation system was also established with use of biodegradable polymer.

本研究旨在开发治疗 2 型糖尿病的新治疗剂，重点关注胰高血糖素-促胰液素家族神经肽。进行生化研究和构效关系研究以提供新的有前途的神经肽衍生物。为了提高神经肽的治疗依从性，还利用可生物降解的聚合物建立了缓释干粉制剂系统。

项目成果

Development of Inhalable Sustained-Release Formulation of Glucagon.

胰高血糖素可吸入缓释制剂的开发。

• 发表时间: 2011
• 作者: Satomi Onoue;Kazuki Kuriyama;Atsushi Uchida;Takahiro Mizumoto;Shizuo Yamada
• 通讯作者: Shizuo Yamada

Stable dry powder inhaler formulation of tranilast attenuated antigen-evoked airway inflammation in rats

• DOI: 10.1016/j.ejpb.2010.11.005
• 发表时间: 2011-01-01
• 期刊: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
• 影响因子: 4.9
• 作者: Kawabata, Yohei;Aoki, Yosuke;Yamada, Shizuo
• 通讯作者: Yamada, Shizuo

Phrmacokinetics and pharmacodynamics of glucagon-loaded PLGA nanospheres for inhalation therapy.

用于吸入治疗的负载胰高血糖素的 PLGA 纳米球的药物动力学和药效学。

• 发表时间: 2010
• 作者: 栗山和樹;尾上誠良;ほか
• 通讯作者: ほか

Neurotrophic activities of newly developed pituitary adenylate cyclase activating polypeptide derivatives in central and peripheral nervous systems.

新开发的垂体腺苷酸环化酶激活多肽衍生物在中枢和周围神经系统中的神经营养活性。

• 发表时间: 2010
• 作者: 上野崇宏;Bahaa G. Youssif;河野樹;岡部泰之;奥田健介;門之園哲哉;近藤科江;永澤秀子;Satomi Onoue
• 通讯作者: Satomi Onoue

Inhalable powder formulation of vasoactive intestinal peptide derivative, [R15,20,21, L17]-VIP-GRR, attenuated neutrophilic airway inflammation in cigarette smoke-exposed rats.

• DOI: 10.1016/j.ejps.2010.08.007
• 发表时间: 2010-11
• 期刊: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
• 作者: S. Onoue;S. Misaka;Yosuke Aoki;Shin-Ichiro Karaki;A. Kuwahara;Asami Ohide;T. Mizumoto;S. Yamada