Cross-talk of zinc transporter and Ca channels in cellular transport of cadmium

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Cadmium(Cd) is a heavy metal widely distributed in the environment and causes adverse effects in a variety of organisms including humans. However, the mechanisms of cellular cadmium uptake and excretion have been poorly understood. It has been assumed that cellular Cd uptake is mediated by pathways for other essential elements such as Ca and Zn. The present study examined the involvement of Zn transporter and Ca channel in cellular Cd transport (influx and efflux) by using a cell line in which the expression of Zn transporter and Ca channel was changed.