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IDENTIFICATION OF KEY FACTORS IN CISPLATIN-INDUCED NEPHROTOXICITY BY MICROARRAY ANALYSIS USING THE ISOLATED RENAL TUBULES

IDENTIFICATION OF KEY FACTORS IN CISPLATIN-INDUCED NEPHROTOXICITY BY MICROARRAY ANALYSIS USING THE ISOLATED RENAL TUBULES
使用分离的肾小管通过微阵列分析鉴定顺铂引起的肾毒性的关键因素
批准号:
20790133
负责人:
YONEZAWA Atsushi
金额:
$2.66万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009

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中文摘要
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英文摘要
Kidney consists of several renal segments. To clarify the gene expression profile in the renal tubule, which is the origin of cisplatin-induced nephrotoxicity, microarray analysis using the isolated tubules was carried out. At first, we confirmed that this experimental method reflected the tubular gene expression. In the isolated tubules of cisplatin-treated rats, the gene expression of chemokines was elevated. Chemokines are suggested to be the key factors of the renal tubular genes in cisplatin-induced nephrotoxicity.
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会议论文
IDENTIFICATION OF HUMAN AND RAT NOVEL RIBOFLAVIN TRANSPORTER RFT1 BASED ON THE IN SILICO GENE EXPRESSION DATABASE.
基于计算机基因表达数据库的人和大鼠新型核黄素转运蛋白 RFT1 的鉴定。
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [橋本真弥, 米澤淳, 桂敏也, 乾賢一, 橋本真弥, Atsushi Yonezawa]
通讯作者: Atsushi Yonezawa
腎排泄型カチオン性薬物メトホルミンのクリアランス予測因子の探索
寻找经肾排泄的阳离子药物二甲双胍的清除预测因子
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [米澤淳, 他, 遠山佳奈]
通讯作者: 遠山佳奈
DOI: 10.1016/j.bcp.2008.07.005
发表时间: 2008-10-01
期刊: BIOCHEMICAL PHARMACOLOGY
影响因子: 5.8
作者: [Sato, Tomoko, Masuda, Satohiro, Inui, Ken-ichi]
通讯作者: Inui, Ken-ichi
DOI: 10.1124/dmd.108.023168
发表时间: 2008-11-01
期刊: DRUG METABOLISM AND DISPOSITION
影响因子: 3.9
作者: [Yokoo, Sachiko, Masuda, Satohiro, Inui, Ken-ichi]
通讯作者: Inui, Ken-ichi
15
    Pathophysiology of riboflavin transporter deficiency for developing therapeutic drugs
    • 批准号:
      24590190
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.49万
    • 财政年份:
      2012
    • 负责人:
      YONEZAWA Atsushi
    • 依托单位:
    Pathophysiological role of riboflavin transporter RFT based on the clinical data
    • 批准号:
      22790154
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $2.58万
    • 财政年份:
      2010
    • 负责人:
      YONEZAWA Atsushi
    • 依托单位:
    海外基金