Functional analysis of miRNA dependent cisplatin resistance mechanisms.

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Cisplatin is an effective anticancer agent that is widely used in the treatment of cancer. However, the development of resistance to cisplatin is a major obstacle to treatment. To understand the clinically relevant mechanisms of resistance, many studies have been aimed at clarifying the biochemical/molecular alterations of cisplatin-resistance cells. However, these studies did not conclusively identify the basis of cellular resistance to cisplatin.In this study, micro RNA expression profiles of cisplatin resistant cell lines were analyzed using microarray and real time RT-PCR. We found some of micro RNAs were similarly regulated in couple of cisplatin resistant non small lung cancer cell lines. These finding were useful information for understanding of the miRNA mediated cisplatin resistance mechanisms.