Construction of the miRNA database associate with chemotherapeutic sensitivity in lung cancer.

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Gefitinib has been used for treatment of non-small cell lung cancer. The EGFR gene mutation correlates with clinical response to Gefitinib. However, some patients are resistant to Gefitinib despite the existence of mutated EGFR gene. This resistance is a major problem in patients with NSCLC. Sensitive biomarker is required for effective therapy with chemotherapeutic drugs. Recently, circulating tumor cell and microRNA(miRNA) are focused on as biomarkers for cancer diagnosis.In this study, we utilized miRNA array and real-time PCR to show that some miRNAs are significantly up-regulated in Gefitinib resistant lung cancer cell lines. Using the miRNA specific inhibitors, we identified ErbB family molecules are as a target gene of these miRNAs.