A novel molecular complex formed by paracellin-1 involved in the regulation of magnesium reabsorption

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Magnesium ion is reabsorbed in the renal tubule. The transport pathway and regulatory mechanisms of magnesium reabsorption have not been clarified yet. We found that paracellin-1 is distributed at the tight junction and regulates a paracellular magnesium transport. The intracellular distribution of paracellin-1 was regulated by the formation of complexes with various phosphorylated proteins. Magnesium deficiency induces cardiovascular diseases such as hypertension and arrhythmia. To avoid magnesium deficiency, the magnesium reabsorption is rigorously controlled by the paracellin-1 complexes.