The effects of sex-specific, developmental stage-dependent environments on the declines of cognitive functions followed by aging

本研究的目的是确定性别特异性的饮食摄入量和动量，防止胆碱能神经元的活性下降，从老化。在这项研究中，我们意外地发现，出生后第9天和第11天经历营养不良的雄性大鼠表现出社会缺陷，而感知、运动功能和认知功能没有异常。在雌性动物中未观察到这些异常。这些结果表明，发育大脑功能的适当环境是性别依赖的，雄性大鼠在婴儿期容易受到营养不良的影响，成年后的情感和社会性。

The purpose of this study is to identify the sex-specific dietary intake and momentum which prevent the decline of the activity in the cholinergic neurons from aging. In this research, we accidentally found that the male rats experiencing the undernutrition on postnatal day 9 and 11 showed social deficits without abnormalities in perception, motor functions, and cognitive functions. These abnormalities were not observed in females. These results suggest that the appropriate environments to develop brain functions are sex dependent, and that male rats are vulnerable to the undernutrition during infancy affecting the emotionality and sociality in adult life.