Investigation of the sex-specific rearing conditions to develop adaptive emotionality and sociability

我们发现，在应激低反应期（SHRP）中，母性剥夺增加了雄性大鼠的一种焦虑相关行为，并减少了社交行为。由于许多研究已经提供证据表明，在精神分裂症的神经发育假说背景下，对我们的结果和先前的研究的解释表明，在大鼠的精神分裂症的精神分裂症的一些积极和消极方面的模型中，在精神分裂症的神经发育假说的背景下，母亲在精神分裂症的一些积极和消极方面被剥夺。为了在可能的精神分裂症症状动物模型的背景下研究在SHRP中经历母性剥夺的大鼠的神经化学特征，我们检测了母性剥夺大鼠海马中钙调神经磷酸酶的表达，发现在母性剥夺的雄性大鼠中钙调神经磷酸酶的表达减少

We found that maternal deprivation in the middle of a stress hyporesponsive period (SHRP) increased a type of anxiety-related behaviour and decreased social behaviour in male rats. Since numerous studies have provided evidence that maternal deprivation in the middle of a SHRP causes multiple behavioural and physiological abnormalities that mimic positive symptoms of schizophrenia in humans, an interpretation of our results and previous studies in the context of the neurodevelopmental hypothesis of schizophrenia suggests that maternal deprivation in the middle of the SHRP in rats models some positive and negative aspects of schizophrenia. To investigate the neurochemical characteristics of rats that experience maternal deprivation in the middle of the SHRP in the context of a possible animal model of the symptoms of schizophrenia, we examined calcineurin expression in the hippocampus of maternally deprived rats and found the decreased calcineurin expression in the maternally deprived male rats