Regulation of dendritic voltage gated ion channels by neurotransmitters.

神经递质对树突电压门控离子通道的调节。

• 批准号: 20790211
• 负责人: NURIYA Mutsuo
• 金额: $ 2.66万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790211/
• 关键词: 神経伝達物質; 電位依存性チャネル; 翻訳後修飾; 神経細胞

In this study, regulations of voltage gated ion channels in neurons, which are considered to play key roles in neuronal physiology, were studied. Pharmacological investigations revealed that these channels are regulated by neuronal activity, which in turn contribute to the maintenance of their activities. In addition, a novel microscopy technique that allows investigation of neuronal activities has been developed and applied to reveal the nature of voltage information processing in axons. Therefore, this study revealed new cellular mechanisms by which neurons maintain their overall activities and also provided a new microscopic technique that can be applied to future physiological researches.

本研究主要研究神经元内电压门控离子通道的调控，它被认为在神经元生理学中起着关键作用。药理学研究表明，这些通道受神经元活动的调节，这反过来又有助于维持它们的活动。此外，一种新的显微镜技术，允许调查的神经元活动已被开发和应用，以揭示轴突的电压信息处理的性质。因此，本研究揭示了神经元维持其整体活动的新的细胞机制，也为未来的生理学研究提供了一种新的显微技术。

项目成果

Second Harmonic Generation (SHG)イメージングによる定量的膜電位計 測

使用二次谐波发生 (SHG) 成像进行定量膜电位测量

• 发表时间: 2008
• 作者: 塗谷睦生;伊藤尚志;安井正人;塗谷睦生;塗谷睦生
• 通讯作者: 塗谷睦生

Regulation of Kv2.1 phosphorylation in an animal model of anoxia

• DOI: 10.1016/j.nbd.2010.01.002
• 发表时间: 2010-04-01
• 期刊: NEUROBIOLOGY OF DISEASE
• 影响因子: 6.1
• 作者: Ito, Takashi;Nuriya, Mutsuo;Yasui, Masato
• 通讯作者: Yasui, Masato

Regulation of Kv4.2 by NMDA receptor activity

NMDA 受体活性对 Kv4.2 的调节

• 发表时间: 2009
• 作者: 塗谷睦生;伊藤尚志;安井正人;塗谷睦生
• 通讯作者: 塗谷睦生

Regulation of Kv4.2 by Neuronal Activity.

神经元活动对 Kv4.2 的调节。

• 发表时间: 2008
• 作者: Mutsuo Nuriya;Takashi Ito;Anne E.Anderson;Masato Yasui
• 通讯作者: Masato Yasui

第二高調波イメージングを用いた神経細胞情報伝達機構の解析

利用二次谐波成像分析神经元信息传递机制

• 发表时间: 2010
• 作者: 齋藤さかえ;他;塗谷睦生
• 通讯作者: 塗谷睦生