Study of the mechanism by which phospholipase C・ regulates proinflammatory cytokine production

Phospholipase C, an intracellular signaling molecule，was implicated inflammation and tumorigenesis by our study of an experimental skin carcinogenesismodel. The aim of this research was to investigate The mechanism of inflammatory reactions mediatedby PLC . This study showed that PLC . plays an important role in regulation of cytokine productionnon-immune cells, such as epidermal keratinocytes and dermal fibroblasts，thereby augmenting inflammation. In addition，keratinocyte-restricted overproduction of PLC in mice results in the development of dermatitisaccompanied by the characteristic features seen in human psoriasissuch as helper T cell infiltration and the development of silvery adherent scales。

Phospholipase C・ (PLC・), an intracellular signaling molecule, was implicated in inflammation and tumorigenesis by our study of an experimental skin carcinogenesis model. The aim of this research was to investigate the mechanism of inflammatory reactions mediated by PLC・. This study showed that PLC・ plays an important role in regulation of cytokine production by non-immune cells, such as epidermal keratinocytes and dermal fibroblasts, thereby augmenting inflammation. In addition, keratinocyte-restricted overproduction of PLC・ in mice results in the development of dermatitis accompanied by the characteristic features seen in human psoriasis, such as helper T cell infiltration and the development of silvery adherent scales.