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Analysis of plasticity of cancer cell motility in 3D substrates

Analysis of plasticity of cancer cell motility in 3D substrates
3D 基底中癌细胞运动的可塑性分析
批准号:
20790254
负责人:
YAMAZAKI Daisuke
金额:
$2.58万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009

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中文摘要
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英文摘要
The motility of cancer cells in 3D matrices is of two types : mesenchymal motility, in which the cells are elongated and amoeboid motility, in which the cells are round. Amoeboid motility is driven by an actomyosin-based contractile force, which is regulated by the Rho/ROCK pathway. Here I show that the motility of elongated cells is regulated by Rac signaling through formation of elongated pseudopodia and cell-substrate adhesion.
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Regulation of actin reorganization by WAVE family proteins during morphogenesis
形态发生过程中 WAVE 家族蛋白对肌动蛋白重组的调节
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [山崎大輔, 栗栖修作, 竹縄忠臣, 山崎大輔, 山崎大輔, 山崎大輔, 山崎大輔]
通讯作者: 山崎大輔
DOI: 10.1038/onc.2009.2
发表时间: 2009-04-01
期刊: ONCOGENE
影响因子: 8
作者: [Yamazaki, D., Kurisu, S., Takenawa, T.]
通讯作者: Takenawa, T.
がん細胞におけるアクチン細胞骨格制御因子の役割
肌动蛋白细胞骨架调节剂在癌细胞中的作用
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [山崎大輔, 栗栖修作, 竹縄忠臣, 山崎大輔, 山崎大輔, 山崎大輔, 山崎大輔, 山崎大輔]
通讯作者: 山崎大輔
Synthesis of boron-doped diamond and its applications to material development and high pressure experiments
  • 批准号:
    23654189
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
  • 资助金额:
    $2.08万
  • 财政年份:
    2011
  • 负责人:
    YAMAZAKI Daisuke
  • 依托单位:
Regulation of lamellipodial dynamics by oscillation of Rac1 activity
  • 批准号:
    23790335
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
  • 资助金额:
    $2.75万
  • 财政年份:
    2011
  • 负责人:
    YAMAZAKI Daisuke
  • 依托单位:
The Mutual Intelligibility of Different World English Varieties : The Correlation between Production and Perception and the Measurable Effects of Prosodic Parameters on Intelligibility
  • 批准号:
    21820062
  • 项目类别:
    Grant-in-Aid for Research Activity Start-up
  • 资助金额:
    $0.81万
  • 财政年份:
    2009
  • 负责人:
    YAMAZAKI Daisuke
  • 依托单位:
Rheology of post-perovskite and the lowermost lower mantle inferred from high pressure experiments
  • 批准号:
    21340128
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 资助金额:
    $11.9万
  • 财政年份:
    2009
  • 负责人:
    YAMAZAKI Daisuke
  • 依托单位:
海外基金