Regulation of lamellipodial dynamics by oscillation of Rac1 activity

Rac1 活性振荡对片状足动力​​学的调节

• 批准号: 23790335
• 负责人: YAMAZAKI Daisuke
• 金额: $ 2.75万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23790335/
• 关键词: 細胞内情報伝達; シグナル伝達

It has been reported that Rac, one of Rho-family small GTPase, plays an important role in formation of lamellipodia. However, the regulatory mechanism of Rac activity remains unknown. In this study, it becomes clear that srGAP1 regulates lamellipodial dynamics through the control of Rac activity. The proper control of Rac activity at laemllipodia is important for efficient migration.

Rac是Rho家族的一种小G蛋白，在板状伪足的形成中起重要作用。然而，Rac活性的调节机制仍然未知。在这项研究中，很明显，srGAP 1通过控制Rac活性来调节片状脂质动力学。在毛足的Rac活性的适当控制是重要的有效迁移。