Regulation of lamellipodial dynamics by oscillation of Rac1 activity
Regulation of lamellipodial dynamics by oscillation of Rac1 activity
批准号:
23790335
负责人:
YAMAZAKI Daisuke
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
Rac是Rho家族小分子GTP酶之一,已有报道在片状脂血症的形成中起重要作用。然而,RAC活性的调控机制仍不清楚。在本研究中,很明显,srGAP1通过控制Rac活性来调节膜脂动力学。适当地控制莱姆利迪亚的RAC活性对于有效的迁徙是很重要的。
英文摘要
It has been reported that Rac, one of Rho-family small GTPase, plays an important role in formation of lamellipodia. However, the regulatory mechanism of Rac activity remains unknown. In this study, it becomes clear that srGAP1 regulates lamellipodial dynamics through the control of Rac activity. The proper control of Rac activity at laemllipodia is important for efficient migration.
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