Lung cancer and Smoking : Effect of cigarette smoke extra on nuclear receptors

近年来，性类固醇激素如雌激素被认为在肺癌中起一定作用。在这项研究中，我们证明了香烟烟雾冷凝物（CSC）具有雌激素样作用，通过雌激素受体在体外。在肺癌患者中，使用定量RT-PCR评估患者吸烟史和CYP 19表达之间的相关性。我们的研究结果表明，吸烟可能通过细胞因子信号增加CYP 19的表达。这些结果均提示吸烟可直接和/或间接刺激肺癌组织中的雌激素信号。

Recently, sex steroid hormones such as estrogen have been considered to play some roles in lung cancer. In this study, we demonstrated that cigarette smoke condensate (CSC) has estrogenic action through the estrogen receptor in vitro. In lung carcinoma patients, a correlation was found between the patients smoking history and CYP19 expression evaluated using quantitative RT-PCR. Results from our study suggested that CYP19 expression might be increased smoking through the cytokine signal. These findings all suggested that smoking might stimulate the estrogen signals directly and /or indirectly in lung carcinoma tissues.