The effects of sex steroid hormones on human pulmonary fibrosis

这是第一项研究，以证明组织浓度的雌激素在人类间质性肺炎（IP）/肺纤维化组织。这项研究的结果表明，IP组织中的雌二醇浓度增加的芳香化酶，这是位于肺泡上皮细胞。在小鼠模型中，肺组织中磷酸二酯酶mRNA的表达水平通过雄激素信号而增加。这些结果都表明，性类固醇激素，雌激素和雄激素可能在IP的发展中发挥重要作用。

This is the first study to demonstrate tissue concentration of estrogen in human interstitial pneumonia (IP)/lung fibrosis tissues. Results from this study suggest that estradiol concentration in IP tissue is increased by aromatase, which is located in alveolar epithelial cells. In the result of mice model, expression level of phosphodiesterase mRNA in lung tissue was increased through the androgen signal. These results all suggest that sex steroid hormones, estrogen and androgen may play an important role in the development of IP.