Analysis of sulfotransferases involved in biosynthesis of selectin ligand carbohydrates in ulcerative colitis

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A diffuse lymphocyte infiltrate characterizes ulcerative colitis, and requires at least one of the two molecular interactions: one via L-selectin and peripheral lymph node addressin (PNAd) and the other via α4β7 integrin and mucosal addressin cell adhesion molecule 1 (MAdCAM-1). The present study was undertaken to elucidate the role of post-translational modification of MAdCAM-1 protein with L-selectin ligand carbohydrates in the pathogenesis of ulcerative colitis. In this study, ulcerative colitis disease activity is not regulated by expression of MAdCAM-1 protein itself, but rather by decoration of MAdCAM-1 protein with L-selectin ligand carbohydrates mediated chiefly by sulfation by GlcNAc6ST-1.