Senescence and maintenance mechanism of antigen-specific CD8+ T cells upon repeatitive antigenic challenges.

虽然人们认为记忆性CTL的性质会随着反复的抗原攻击而改变，但具有不同抗原经验的不同记忆性CTL的分子特征在很大程度上是未知的。在这项研究中，我们使用下一代DNA测序仪分析了初级和次级记忆性CTL的全基因组转录组。记忆性CTL在经历反应时会改变分子特征，而记忆性CTL衰老不同于衰竭。

Although it is suggested that the nature of memory CTL changes over repeated antigenic challenges, molecular characteristics of distinct memory CTL with different number of antigen experience are largely unknown. In this study, we analyzed genome wide transcriptome of primary and secondary memory CTL using a next-generation DNA sequencer. Memory CTL changes molecular signature as they experience the responses and memory CTL senescence differs from exhaustion.