Developmental challenges for drug delivery system targetin g to neurodegenerative area

在阿尔茨海默病(AD)的神经退行性变区域，我发现了依赖于淀粉样蛋白(Aβ，Aβ)的肌动蛋白组装相关因子的积聚，并提出了Aβ与突触丢失之间的相关性。这一结果可能预示着治疗AD的新靶点。我还发现，星形胶质细胞在脑缺血的神经退行性变区域释放了DJ-1，一种神经保护因子。这一结果表明，星形胶质细胞作为DJ-1到大脑的递送载体可能是有用的。

In neurodegenerative regions of Alzheimer's disease (AD), I found amyloid-β(Aβ)-dependent accumulation of actin assembly-related factor, and suggested correlations between Aβ and synaptic loss. This result may indicate a new therapeutic target against AD. I also found that astrocytes released DJ-1, a neuroprotective factor, in neurodegenerative regions of brain ischemia. This result suggests a possible usefulness of astrocytes as a delivery carrier for the DJ-1 to brains.