Development of PEGylated thiol modified protein drugs for the treatment of sepsis

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To prevent septic shock and hepatitis, prolonged delivery of reduced thiols to the blood circulation was performed in animals by a bolus intravenous injection of polyethylene glycol (PEG)-conjugated thiols modified serum albumin (PEG-BSA-SH). PEG-BSA-SH exhibited a prolonged retention in the plasma after intravenous injection into mice. PEG-BSA-SH also effectively suppressed the septic shock and hepatitis in the sepsis mouse or rat model. These findings indicate that PEG-BSA-SH is a promising compound for the treatment of septic shock and hepatitis.