Investigation of genetic risk factors for cardiovascular disease in general population.

在本研究中，我们探讨了遗传因素与心血管疾病危险因素之间的关系。据报道，CRP基因上的单核苷酸多态性（SNP） rs1205与血清hsCRP水平相关。在这项研究中，我们在日本普通人群中研究了SNP rs1205与作为动脉粥样硬化替代标志物的肱-踝脉波速度（baPWV）之间的可能关联。与TT基因型相比，CC和CT基因型与hsCRP水平升高（p=0.004）和baPWV水平降低（p=0.03）相关，尽管hsCRP水平升高与baPWV水平升高相关。需要进一步的研究来确定CRP上rs1205的C等位基因是否与动脉粥样硬化性血管改变和CVD事件的风险降低相关。

In the present investigation, we examined the association between genetic factor and risk factors of cardiovascular diseases. Single nucleotide polymorphism (SNP) rs1205 on a CRP gene was reported to be associated with serum hsCRP levels. In this study, we examined a possible association between SNP rs1205 and brachial-ankle pulse wave velocity (baPWV) as a surrogate marker for atherosclerosis, in a Japanese general population. Compared with TT genotype, CC and CT genotype was related to increased hsCRP levels (p=0.004) and decreased baPWV levels (p=0.03), although increased hsCRP levels were associated with increased baPWV levels. Further studies are needed to determine whether C allele of rs1205 on CRP predict are associated with decreased risk of atherogenic vascular change and CVD events.