The association between BNP level, NPPB genotype and CVD risk in general Japanese population.

日本普通人群中 BNP 水平、NPPB 基因型与 CVD 风险之间的关联。

• 批准号: 22790544
• 负责人: TAKASHIMA Naoyuki
• 金额: $ 2.41万
• 依托单位: Shiga University of Medical Science
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790544/
• 关键词: NPPB遺伝子多型; 脳性ナトリウム利尿ペプチド; 左室肥大; 循環器疾患発症; 予防医学; 循環器・高血圧; 社会医学; 分子疫学

Brain natriuretic peptide (BNP) is a clinical useful marker forheart failure. In the present study, we observed the significant association between plasma BNP levels and electrocardiographic left ventricular hypertrophy. However, we did not find the significant association between electrocardiographic left ventricular hypertrophy and the NPPB genotype. Furthermore, we did not find any significant association between the NPPB genotype and future cardiovascular disease risk. Therefore, it is needed for further research to examine the association between CVD risk and the NPPB genotype.

脑钠肽（BNP）是临床上有用的心力衰竭标志物。在本研究中，我们观察到血浆 BNP 水平与心电图左心室肥厚之间存在显着相关性。然而，我们没有发现心电图左心室肥厚与 NPPB 基因型之间存在显着关联。此外，我们没有发现 NPPB 基因型与未来心血管疾病风险之间存在任何显着关联。因此，需要进一步研究 CVD 风险与 NPPB 基因型之间的关联。