Regulation of Wnt signaling by activated innate immunity in intestinal epithelium.

我们研究了微环境如何调节胃肠道上皮细胞的生长。由上皮细胞分泌的IL-6显示通过STAT 3激活来调节细胞生长，可能是通过STAT 3使β-连环蛋白核转位并导致Wnt信号传导激活。先天免疫对肠道微环境的调节作用已被报道，但先天免疫与Wnt信号通路之间的相互作用有待进一步研究。

We investigated how microenvironment regulates cell growth in gastrointestinal epithelium. IL-6 secreted by epithelial cells was shown to regulate cell growth through STAT3 activation, probably via the nuclear translocation of beta-catenin by STAT3 and resulting Wnt signaling activation. Innate immunity has been reported to regulate intestinal microenvironment, and the crosstalk between innate immunity and Wnt signaling shoud be further analyzed.