Roles of nardilysin and ADAM proteases in the regulation of gastric cancer cell growth.

据报道，Nardilysin（NRDc）与ADAM蛋白（例如ADAM 17）合作，促进各种生长因子前体形式的胞外域脱落。NRDc在胃癌组织的癌上皮中表达频繁升高。NRDc表达下调后，胃癌细胞生长受到抑制。在胃癌细胞中，NRDc促进pro-TNF-α的胞外域脱落，导致多种细胞因子如IL-6的转录上调。因此，NRDc通过激活STAT 3维持生长相关基因的表达。

Nardilysin(NRDc) has been reported to promote ectodomain shedding of the precursor forms of various growth factors in cooperation with ADAM proteins such as ADAM17. NRDc expression was frequently elevated in the cancer epithelium of gastric cancer tissues. After knockdown of NRDc expression, gastric cancer cell growth was suppressed. In gastric cancer cells, NRDc promotes ectodomain shedding of pro-TNF-alpha, leading to the upregulated transcription of various cytokines such as IL-6. As a result, NRDc maintains the expressions of growth-related genes via activated STAT3.