Identification and character ization of novel transcription programs required for lipid synthesis in the liver

肝脏脂质合成所需的新型转录程序的鉴定和表征

• 批准号: 20790496
• 负责人: HARADA Nagakatsu
• 金额: $ 2.66万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790496/
• 关键词: 脂質合成; 遺伝子; 転写; マウス; 脂肪肝; mRNAバリアント; プロモーター

Glycerol-3-phosphate acyltmnsferase (GPAT) acts as a rate limiting enzyme in de novo lipid synthesis. GPAT is now a candidate for targeted treatment of the excess lipid accumulation that is associated with obesity and Non-alcoholic Fatty Liver Disease. In the present study, I clarified mechanisms of enhanced GPAT gene expression induced by feeding or obesity using cultured cells and mice.

甘油-3-磷酸酰基化酶（GPAT）在新生脂质合成中起限速酶的作用。GPAT现在是靶向治疗与肥胖和非酒精性脂肪性肝病相关的过量脂质积累的候选药物。在本研究中，我利用培养细胞和小鼠阐明了饲养或肥胖诱导GPAT基因表达增强的机制。

项目成果

Identification of cis-acting promoter sequences required for expression of the glycerol-3-phosphate acyltransferase 1 gene in mice

小鼠中甘油-3-磷酸酰基转移酶 1 基因表达所需的顺式作用启动子序列的鉴定

• 发表时间: 2009
• 期刊: Biochim Biophys Acta 1791
• 作者: Nakagasva T;Yin Y;Hattori A;Zenitani T;Hara S;Yonemoto H;Nakamura A;Nakano M;Mawatari K;Teshigawara K;Arai H;Hosaka T;Takahashi A;Yoshimoto K. Nakaya Y
• 通讯作者: Yoshimoto K. Nakaya Y

High density lipoprotein inhibits the activation of sterol regulatory element‐binding protein‐1 in cultured cells

高密度脂蛋白抑制培养细胞中甾醇调节元件结合蛋白-1的活化

• DOI: 10.1016/j.febslet.2010.02.034
• 发表时间: 2010
• 期刊: FEBS Letters
• 影响因子: 3.5
• 作者: Masaki Yoshida;N. Harada;Keiko Yoshida;Tadahiko Nakagawa;T. Shimohata;K. Mawatari;A. Takahashi;H. Sakaue;Y. Nakaya
• 通讯作者: Y. Nakaya