The study of pathogenesis during respiratory tract infection usingCCL1 gene targeted mouse

我们首次建立了一种新的基因靶向小鼠，它可以在表面活性蛋白C（SP-C）启动子的控制下，仅在肺组织中强烈表达CCL 1。到目前为止，我们证实了CCL 1基因靶向小鼠的支气管肺泡液（BALF）中CCL 1的表达显著高于对照小鼠。为了评估CCL 1在呼吸道感染或慢性阻塞性肺病发病过程中的作用，将在这些小鼠中诱导细菌感染或肺气肿。

We originally established novel gene targeted mice, which can strongly express theCCL1 only in the lung tissues under the control of surfactant protein C (SP-C) promoter. To date, we confirmed that significantly higher expression ofCCL1 in bronchial alveolar fluid (BALF) in CCL1 gene targeted mice, compared with control mice. To evaluate the role of CCL1 during the respiratory infection or pathogenesis of chronic obstructive pulmonary disease, bacterial infection or pulmonary emphysema will be induced in these mice.