The study of pathogenesis during respiratory tract infection usingCCL1 gene targeted mouse

CCL1基因靶向小鼠呼吸道感染发病机制研究

• 批准号: 20790563
• 负责人: INOUE Sumito
• 金额: $ 2.75万
• 依托单位: Yamagata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790563/
• 关键词: CCL1; COPD; 呼吸器感染症

We originally established novel gene targeted mice, which can strongly express theCCL1 only in the lung tissues under the control of surfactant protein C (SP-C) promoter. To date, we confirmed that significantly higher expression ofCCL1 in bronchial alveolar fluid (BALF) in CCL1 gene targeted mice, compared with control mice. To evaluate the role of CCL1 during the respiratory infection or pathogenesis of chronic obstructive pulmonary disease, bacterial infection or pulmonary emphysema will be induced in these mice.

我们首次建立了一种新的基因靶向小鼠，它可以在表面活性蛋白C（SP-C）启动子的控制下，仅在肺组织中强烈表达CCL 1。到目前为止，我们证实了CCL 1基因靶向小鼠的支气管肺泡液（BALF）中CCL 1的表达显著高于对照小鼠。为了评估CCL 1在呼吸道感染或慢性阻塞性肺病发病过程中的作用，将在这些小鼠中诱导细菌感染或肺气肿。

项目成果

Effect of antibiotic therapy on the inflammatory responses during streptococcal pneumonia in emphysematous mice.

抗生素治疗对肺气肿小鼠链球菌肺炎炎症反应的影响。

• 发表时间: 2009
• 期刊: EXCLI J 8
• 作者: Inoue S;Nakamura H;Shibata Y;Abe S;Takabatake N;Sata M;Takeda H;Kubota I.
• 通讯作者: Kubota I.

Altered expression of antimicrobial molecules in cigarette smoke-exposed emphysematous mice lungs.

暴露于香烟烟雾的肺气肿小鼠肺部抗菌分子的表达发生改变。

• 发表时间: 2008
• 期刊: Respirology. 13(7)
• 作者: Shibata Y;Abe S;Inoue S;Takabatake N;Igarashi A;Takeishi Y;Sata M;Kubota I
• 通讯作者: Kubota I

Exercise tolerance in patients with chronic obstructive pulmonary disease is independent of resting pulmonary or cardiac functions.

慢性阻塞性肺疾病患者的运动耐量与静息肺功能或心脏功能无关。

• 发表时间: 2010
• 作者: Kishi H;Shibata Y;et al.
• 通讯作者: et al.

Gly80Ser Polymorphism of Phospholipase A2-IID Is Associated with Cytokine Inducibility in A549 Cells

• DOI: 10.1159/000213243
• 发表时间: 2009-01-01
• 期刊: RESPIRATION
• 影响因子: 3.7
• 作者: Igarashi, Akira;Shibata, Yoko;Kubota, Isao
• 通讯作者: Kubota, Isao

A novel polymorphism in CDC6 is associated with the decline in lung function of ex-smokers in COPD

• DOI: 10.1016/j.bbrc.2009.02.080
• 发表时间: 2009-04-17
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Takabatake, Noriaki;Toriyama, Sayumi;Kubota, Isao
• 通讯作者: Kubota, Isao