Exploring the mechanism of rTMS therapeutic effects on writer's cramp

患书写痉挛症的病人由于不自主的动作而不能很好地握笔。重复经颅磁刺激（rTMS）作为书写痉挛的非侵入性低压力程序引起了人们的注意。然而，rTMS临床应用的最佳条件及其治疗作用机制尚未完全清楚。本研究的结果提示，在运动前区刺激时，单相（相位）和0.2Hz（频率）分别比双相和1Hz更有效，并且rTMS的治疗效果可能来自于影响运动控制的躯体感觉输入。

Patient with writer's cramp can not take their pen in their hand well because of their involuntary movement. Repetitive transcranial magnetic stimulation (rTMS) is drawing attention as the non-invasive low-stressful procedure to Writer's cramp. However, the optimum conditions of rTMS to clinical application and its mechanism of therapeutic effects have not been well-known. The results of our present studies suggest that monophasic (phase) and 0.2Hz (frequency) are more effective than biphasic and 1Hz respectively in the case of stimulating on the premotor area, and also the possibility that the therapeutic effects of rTMS is derived from influencing the incoming somatosensory input for motor control.