Identification of the new gene for familial parkinsonism and its functional analyses

为了确认常染色体隐性晚发性家族性帕金森病（ARLOPD）的新候选基因的发病机制，我对大约900名帕金森病患者进行了突变筛查。虽然我在两名患者身上检测到了杂合突变，但我仍然不能断定该基因是否是ARLOPD的决定性致病基因。另外，我找到了ARLOPD的新位点。需要进一步的研究来确定ARLOPD的致病基因。

To confirm the pathogenesis of the novel candidate genes for autosomal recessive-late onset familial Parkinson disease (ARLOPD), I performed mutation screening in approximately 900 patients with Parkinson disease. Although I detected the heterozygous mutation in two patients, I still cannot conclude whether the gene is the definitive causal gene for ARLOPD. In addition, I found the new locus for ARLOPD. Further investigation is needed to identify the causal gene for ARLOPD.