Regulatory role of AMP-kinase in the paraventricular hypothalamus in calorie intake and food preference.

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Hypothalamic AMP-kinase regulates feeding behavior in response to hormonal and nutrient signals. Here I report that preferential expression of constitutively-active AMP-kinase (CA-AMPK) in the PVH blilaterally using lenti-virus vector (neuron specific-synapsin 1 promoter) increased food intake and body weight under lab chow diet. Furthermore, CA-AMPK mice increased the preference for high carbohydrate diet, by enhancing fatty acid oxidation in the PVH. In contrast, diet-induced as well as KKAy obese mice increased the preference for HFD, associated with paradoxically decreased AMPK activity and FAO in the PVH.Thus, my results suggest that AMPK-FAO in the PVH regulates the preference for carbohydrate and fat diets. Furthermore, obese mice impair the AMPK-FAO system in the PVH and thereby increase HFD intake