The molecular mechanism of IL-25-mediated allergic airway inflammation

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We showed that IL-25 expression is increased in the airway of experimental mouse model of asthma and that neutralization of IL-25 by soluble IL-25 receptor-Fc fusion protein suppresses eosinophilic inflammation in experimental mouse model of asthma. We also established intracellular IL-25 staining method using soluble IL-25 receptor-Fc fusion protein and has found that the cytokine profile of IL-25 producing CD4+T cells is not identical to that of Th2 cells. Furthermore, we found that the lung-specific IL-25 expression not only exacerbates allergic airway inflammation, but also induces pulmonary arteriolitis and marked remodeling of vascular wall, which is now under detailed investigation.