Analysis of rotavirus antigenemia in hepatopoietic stem cell transplanted children

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We've already reported that rotavirus antigenemia has been found in immunocompetent rotavirus gastroenteritis patients. However, the pathogenesis of rotavirus infection in immunocompromised transplant recipients remains unclear. Serially collected serum samples obtained from the patients receiving allogeneic hematopoietic stem cell transplants were measured rotavirus antigen levels using a previously established enzyme-linked immunosorbent assay.Rotavirus antigenemia occurred in hematopoietic stem cell transplant (HSCT) recipients. Although the duration of antigenemia was clearly longer than in immunocompetent rotavirus gastroenteritis patients, the levels of antigen were not as high.