Research for fetal or developmental period origins of adult disease with animal models.

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Maternal high fat environment make a hypertensive offspring, but regulation of fat feeding during lactation period may reduce adulthood hypertension. In case with normal food, restrictive feeding during late gestation is more effective than lactation period for inducing hypertensive male offspring. Regulation of maternal feeding not only during late gestation but also lactation period may control adulthood hypertension. Fetal origin of adult hypertension might be vascular endothelial dysfunction.Inflammatory responses in F1 female mice are similar to the uterine environment in production of NOx. Therefore, a maternally-derived iNOS mutation is important in inflammatory responses of aged females respectively.