Explore of schizophrenia susceptible genes based on the findings in postmortem study

基于尸检结果探讨精神分裂症易感基因

• 批准号: 20790838
• 负责人: FUKUTAKE Masaaki
• 金额: $ 2.66万
• 依托单位: Kobe University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790838/
• 关键词: 統合失調症; 自殺; 相関研究; 遺伝子多型; SNP; ハプロタイプ; 死後脳; meta-analysis; 相関; NOS1; DNA chip; tryptophan hydroxylase; セロトニン; tag SNP; kruppel-like factor 5

Focusing on the biological vulnerability on which the pathogenesis of schizophrenia have been considered to be based, we have explored the genetic variants of schizophrenia susceptible genes. We have conducted association analysis of the interest genetic varints with schizophrenia based on the hypothesis such as the neurodevelopment model of schizophrenia. In addition, we have approached the subject from another perspective to identify the novel schizophrenia susceptible genetic variants using DNA microarray experiments to the postmortem study of schizophrenia, and based on the findings of the microarray analysis, we have conducted further association analysis. As a result, we have identified several important genetic variants associated with schizophrenia.

精神分裂症的发病机制一直被认为是基于生物脆弱性，我们已经探讨了精神分裂症易感基因的遗传变异。我们基于精神分裂症的神经发育模型等假设，对感兴趣的遗传变异与精神分裂症进行了关联分析。此外，我们从另一个角度探讨了这个问题，以精神分裂症的尸检研究为基础，利用DNA微阵列实验来识别新的精神分裂症易感基因变异，并根据基因芯片分析的结果，我们进行了进一步的关联分析。因此，我们已经确定了几个重要的遗传变异与精神分裂症。

项目成果

Association of alpha2A-adrenergic receptor gene polymorphism with susceptibility to suicide in Japanese females

α2A-肾上腺素受体基因多态性与日本女性自杀易感性的关系

• 发表时间: 2008
• 期刊: Prog Neuropsychopharmacol Biol Psychiatry 1 ; 32(6)
• 作者: Fukutake M;Hishimoto A;Nishiguchi N;Nushida H;Ueno Y;Shirakawa O;Maeda K.
• 通讯作者: Maeda K.

Association of RGS2 gene Polymorphisms with suicide and increased RGS2 immunoreactivity in the postmortem brain of suicide victims

• DOI: 10.1038/sj.npp.1301557
• 发表时间: 2008-06-01
• 期刊: NEUROPSYCHOPHARMACOLOGY
• 影响因子: 7.6
• 作者: Cui, Huxing;Nishiguchi, Naoki;Shirakawa, Osamu
• 通讯作者: Shirakawa, Osamu

精神科外来における統合失調症患者に対するblonanserinの使用経験

精神科门诊精神分裂症患者使用布南色林的经验

• 发表时间: 2009
• 期刊: 臨床精神薬理誌 Vol.12 No.9
• 作者: 菱本明豊;福武将映;山本泰司;他
• 通讯作者: 他

Expression of Kruppel-like factor 5 gene in human brain and association of the gene with the susceptibility to schizophrenia

• DOI: 10.1016/j.schres.2007.11.042
• 发表时间: 2008-03
• 期刊: Schizophrenia Research
• 影响因子: 4.5
• 作者: M. Yanagi;T. Hashimoto;N. Kitamura;M. Fukutake;O. Komure;N. Nishiguchi;T. Kawamata;K. Maeda;O. Shirakawa

Neurobiology of Suicide

• DOI: 10.3109/9780203912485-48
• 发表时间: 2003-03
• 期刊: Translational Psychiatry
• 影响因子: 6.8
• 作者: L. Sher;J. Mann